Bioimaging with Molecular Probes

Professor Kazuya KIKUCHI [ Graduate School of Engineering, Osaka University ]

The next target for research activities in the so-called post-genome age is clarification of functions of genome-related materials under various physiological conditions, and the importance of this technique has been becoming increasingly important.
For achieving the objectives in the research activities in this field, it is important to examin functions of cells in their alive state ( without homogenizing the cells), because more information can be acquired by examining cellular functions in the alive state.
The imaging analysis using the green fluorescent protein(GFP) is now generally employed for achieving the objectives, and the technique is the standard one employed in almost all laboratories.
Almost 30 years passed since discovery of the GFP in 1962 until actual application of the GFP started in 1994.What kind of studies were made in this ””blank ””period?Let’s look back to the recent history of research activities in the field of chemical biology for imaging, and you also learn the organic molecular probes as well as on the fluorescent protein probes through this lecture.

Professor Kazuya KIKUCHI [ Graduate School of Engineering, Osaka University ]

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